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To explore the potential role of polymers in the development of drug-delivery systems, this study investigated the use of β-cyclodextrin (β-CD), carboxymethyl cellulose (CMC), acrylic acid (AA) and N’ N’-methylenebis-acrylamide (MBA) in the synthesis of hydrogels for controlled drug delivery of acyclovir (ACV). Different proportions of β-CD, CMC, AA and MBA were blended with each other to fabricate hydrogels via free radical polymerization technique. Fourier transform infrared spectroscopy (FTIR) revealed successful grafting of components into the polymeric network. Thermal and morphological characterization confirmed the formation of thermodynamically stable hydrogels having porous structure. The pH-responsive behaviour of hydrogels has been documented by swelling dynamics and drug release behaviour in simulated gastrointestinal fluids. Drug release kinetics revealed controlled release behaviour of the antiviral drug acyclovir in developed polymeric network. Cross-linked β-cyclodextrin and carboxymethyl cellulose hydrogels can be used as promising candidates for the design and development of controlled drug-delivery systems.

Introduction Hydrogels are hydrophilic polymeric network, with the ability to absorb large quantities of water and having physicochemical characteristics which make them suitable for use in human tissues[]. They provide good platform for the development of polymeric drug delivery systems. However, their ability for use in pharmaceuticals is mainly dependant on their mechanical strength, their drug loading potential and controlled drug release behaviour[]. Despite all this, some drawbacks are still associated with hydrogels, when used as delivery system for drugs, such as decreased drug loading strength for hydrophobic drugs as well as less control over drug release mechanism[]. To overcome all these drawbacks, cyclodextrin based hydrogels have been developed. Cyclodextrin (CDs) based hydrogels have the benefits of enhanced swelling capability and augmented encapsulation efficiency for the loaded drug[]. Cyclodextrins are classified as cyclic oligosaccharides with both hydrophilic and hydrophobic surface, formed from the breakdown of starch by cyclodextringluconotransferase and having remarkable potential to form inclusion complexes with a large number of molecules[].